The NA inhibitors bind to the influenza neuraminidase enzyme active site, inhibiting the release of virions from the infected cells… † Use is not currently included in the labeling approved by the US Food and Drug Administration. It works by stopping the spread of the flu virus in the body. CDCHAN-00378. Table 1. June 2, 2015. Peramivir hemmt die virale Neuraminidase. 3 Wirkmechanismus. Accessed 2019 Apr 15. Calculated using the Cockcroft and Gault equation. Update: Influenza Activity in the United States During the 2016-17 Season and Composition of the 2017-18 Influenza Vaccine. H5N1 influenza pandemic: contingency plans. From WHO website. Chemical Name: 3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid hydrate hospitalization [see Indications and Usage (1) and Clinical Studies (14.2)]. 105. 2015; 117:27-38. http://www.ncbi.nlm.nih.gov/pubmed/25721488?dopt=AbstractPlus, 182. Significantly increased drug exposures were observed when RAPIVAB was administered to adult, subjects with renal dysfunction [see Clinical Pharmacology (12.3)]. Gubareva LV, Webster RG, Hayden FG. tell your doctor if you have or have ever had kidney disease. 1408 0 obj <>stream From WHO website. The maximum concentration of peramivir in, milk was reached at 0.75 hours post-dose. Ringer's. Peramivir injection will not prevent bacterial infections, which may occur as a complication of the flu. Use of RAPIVAB for this indication is supported by evidence, from adequate and well-controlled trials of RAPIVAB in adults with additional data from Study 305, a, randomized, active-controlled trial of 110 adolescent and pediatric subjects with acute uncomplicated, influenza who received open-label treatment with a single dose of RAPIVAB or 5 days of treatment, with oseltamivir administered within 48 hours of onset of symptoms of influenza [see Dosage and. The pharmacokinetics of peramivir has not been studied in pediatric subjects with renal impairment. Recommended composition of influenza virus vaccines for use in the 2013–2014 northern hemisphere influenza season. The molecular structure is as follows: RAPIVAB injection is a clear, colorless, sterile, isotonic solution (200 mg per 20 mL) in glass vials, fitted with rubber stoppers and royal blue flip-off seals. MMWR Morb Mortal Wkly Rep. 2013; 62:473-9. http://www.ncbi.nlm.nih.gov/pubmed/23760189?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=4604847&blobtype=pdf, 552. . McEvoy, GK, ed. Each vial of RAPIVAB injection contains 200 mg per 20 mL (10 mg per mL) as a clear, colorless. 0.9% Sodium Chloride Injection, USP is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container. 2013; 88:101-14. http://www.ncbi.nlm.nih.gov/pubmed/23544236?dopt=AbstractPlus, 553. established. Centers for Disease Control and Prevention. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. MMWR Morb Mortal Wkly Rep. 2015; 64:583-90. http://www.ncbi.nlm.nih.gov/pubmed/26042650?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=4584770&blobtype=pdf, 562. . exposures approximately 8 times those in humans at the recommended dose. 2018; 93:133-41. http://www.ncbi.nlm.nih.gov/pubmed/29569429?dopt=AbstractPlus, HID. Race: Pharmacokinetics of peramivir was evaluated primarily in Caucasians and Asians. 2018; 142 http://www.ncbi.nlm.nih.gov/pubmed/30177511?dopt=AbstractPlus. solution [see How Supplied/Storage and Handling (16)]. American Academy of Pediatrics. Centers for Disease Control and Prevention. Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection. Pharmacokinetics of, peramivir in subjects 2 to 12 years of age (C, administered a single 12 mg/kg dose was also similar to that in adult subjects administered a single 600, Geriatric Patients: Peramivir pharmacokinetics in elderly subjects was similar to non-elderly, subjects. who have been symptomatic for no more than 2 days. http://www.ncbi.nlm.nih.gov/pubmed/28841201?dopt=AbstractPlus, 104. Recommendations. There is no specific antidote for overdose with. Tsang KWT, Eng P, Liam CK et al. Centers for Disease Control and Prevention. Visually inspect RAPIVAB for particulate matter and discoloration prior to administration. 2009; 360:2605-15. http://www.ncbi.nlm.nih.gov/pubmed/19423869?dopt=AbstractPlus, 134. These events were reported primarily among pediatric patients and often, had an abrupt onset and rapid resolution. Peramivir drug & pharmaceuticals active ingredients names and forms, pharmaceutical companies. Do not use if seal over bottle opening is broken or missing. Clin Infect Dis. Centers for Disease Control and Prevention.

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